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Covariate Adjustment
Adjusting for prognostic covariates can significantly increase statistical power and reduce required enrollment in both treatment and control arms.
Real-world evidence (RWE) to reduce the size and duration of clinical trials
Blog Post
Adjusting for Covariates in Randomized Clinical Trials for Drugs and Biological Products
Guidance
Increasing the efficiency of randomized trial estimates via linear adjustment for a prognostic score
Paper
Enhancing Longitudinal Clinical Trial Efficiency with Digital Twins and Prognostic Covariate-Adjusted Mixed Models for Repeated Measures (PROCOVA-MMRM)
Paper
Super-covariates: Using predicted control group outcome as a covariate in randomized clinical trials
Paper
Bayesian Prognostic Covariate Adjustment With Additive Mixture Priors
Paper
Covariate adjustment in Bayesian adaptive randomized controlled trials
Paper
Covariate-adjusted borrowing of historical control data in randomized clinical trials
Paper
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