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Hybrid controls
Hybrid controlled trials leverage both internal and external controls, reducing required enrollment while ensuring comparability of RWD.
Emulating Randomized Controlled Trials with Hybrid Control Arms in Oncology: A Case Study
Paper
Dynamic use of historical controls in clinical trials for rare disease research: a re-evaluation of the MILES trial
Paper
A Simulation-Based Evaluation of Statistical Methods for Hybrid Real-World Control Arms in Clinical Trials
Paper
Comparative Study of Bayesian Information Borrowing Methods in Oncology Clinical Trials
Paper
Trial designs using real‐world data: The changing landscape of the regulatory approval process
Review Article
Semi-supervised mixture multi-source exchangeability model for leveraging real-world data in clinical trials
Paper
Minimizing control group allocation in randomized trials using dynamic borrowing of external control data – An application to second line therapy for non-small cell lung cancer
Paper
