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Registry RCTs
RCTs run in routine practice settings can generate robust causal evidence while better reflecting real-world care and enrolling patients 50% faster.
Real-World Data: Assessing Registries to Support Regulatory Decision-Making for Drug and Biological Products
Guidance
Real-world evidence (RWE) to reduce the size and duration of clinical trials
Blog Post
Registry-based randomised controlled trials: conduct, advantages and challenges—a systematic review
Review Article
Rationale and design of the DAPA-MI trial: Dapagliflozin in patients without diabetes mellitus with acute myocardial infarction
Paper
Registry randomised trials: a methodological perspective
Review Article
CONSORT extension for the reporting of randomised controlled trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE): checklist with explanation and elaboration
Paper
Defining key design elements of registry-based randomised controlled trials: a scoping review
Review Article
Pragmatic randomized controlled trials: strengthening the concept through a robust international collaborative network: PRIME-9—Pragmatic Research and Innovation through Multinational Experimentation
Paper
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