RWD Clinical Trials | Droice Labs

RWD Clinical Trials

Explore how RWD clinical trials leveraging approaches such as external control arms, hybrid controls, pragmatic elements, and covariate adjustment are reducing timelines, costs, and patient burdens.

Covariate Adjustment

Covariate-adjusted borrowing of historical control data in randomized clinical trials

Paper

Hybrid controls

Trial designs using real‐world data: The changing landscape of the regulatory approval process

Review Article

PDS

ECA

Real-World Data as External Controls: Practical Experience from Notable Marketing Applications of New Therapies

Paper

DIA

Registry RCTs

Overcoming the barriers to better evidence generation from clinical trials

Review Article

BMC

Covariate Adjustment

Covariate Adjustment in Cardiovascular Randomized Controlled Trials: Its Value, Current Practice, and Need for Improvement

Review Article

JACC

Hybrid controls

Semi-supervised mixture multi-source exchangeability model for leveraging real-world data in clinical trials

Paper

OP-B

ECA

Considerations for pooling real-world data as a comparator cohort to a single arm trial: a simulation study on assessment of heterogeneity

Paper

BMC

Registry RCTs

Registry-based randomized controlled trials merged the strength of randomized controlled trails and observational studies and give rise to more pragmatic trials

Review Article

JCE