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Hybrid controls
Hybrid controlled trials leverage both internal and external controls, reducing required enrollment while ensuring comparability of RWD.
Real-world evidence (RWE) to reduce the size and duration of clinical trials
Blog Post
Considerations for the Design and Conduct of Externally Controlled Trials for Drug and Biological Products
Guidance
Covariate handling approaches in combination with dynamic borrowing for hybrid control studies
Paper
Using Bayesian Dynamic Borrowing to Maximize the Use of Existing Data: A Case-Study
Review Article
Innovative Hybrid Designs and Analytical Approaches Leveraging Real-World Data and Clinical Trial Data
Book Chapter
Enhancing External Control Arm Analyses through Data Calibration and Hybrid Designs
Review Article
Augmenting external control arms using Bayesian borrowing: a case study in first-line non-small cell lung cancer
Paper
Augmenting control arms with real-world data for cancer trials: Hybrid control arm methods and considerations
Paper
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